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Case Studies

Publications

  • Harumi Jyonouchi Immunological Abnormalities in Autism Spectrum Disorders Advances in Neuroimmune Biology 4, 2013, 141-159
  • Harumi Jyonouchi Non-IgE Mediated Food Allergy - Update of Recent Progress in Mucosal Immunity Inflammation & Allergy - Drug Targets, 2012, 11, 382-396
  • Harumi Jyonouchi, Lee Geng, Pamella Kattouf,Deanna L. Streck and Gokce Toruner Impaired Oral Tolerance in ASD Children with Food Protein Induced Enterocolitis Syndrome (FPIES) - Altered Innate and Adaptive Immune Responses in ASD Children Recovered from FPIES in Comparison with non-ASD/FPIES and ASD/non-FPIES Children Autism – A Neurodevelopmental Journey from Genes to Behaviour
  • Harumi Jyonouchi, Lee Geng, Deanna L. Streck, Gokce A. TorunerChildren with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes J. Neuroimmunol. (2011), doi:10.1016/j.jneuroim.2011.07.001
  • Harumi Jyonouchi Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic Expert Rev Clin Immunol 6(3), 397-411 (2010
  • Harumi Jyonouchi, Chongwei Cui, Lee Geng, Zhiwei Yin, Patricia Fitzgerald-Bocarsly Age-dependent changes in peripheral blood dendritic cell subsets in normal children and children with specific polysaccharide antibody deficiency (SPAD) Eur J Pediatr Published on line in May 2010
  • Timothy Buie, Daniel B. Campbell, George J. Fuchs, III, Glenn T. Furuta, Joseph Levy, Judy VandeWater, Agnes H. Whitaker, Dan Atkins, Margaret L. Bauman, Arthur L. Beaudet, Edward G. Carr, Michael D. Gershon, Susan L. Hyman, Pipop Jirapinyo, Harumi Jyonouchi, Koorosh Kooros, Rafail Kushak, Pat Levitt, Susan E. Levy, Jeffery D. Lewis, Katherine F. Murray, Marvin R. Natowicz, Aderbal Sabra, Barry K. Wershil, Sharon C. Weston, Lonnie Zeltzer and Harland Winter Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report Pediatrics 2010;125;S1-S18
  • Harumi Jyonouchi1, Lee Geng1, Agnes Cushing-Ruby1, Iona M. Monteiro2 Aberrant responses to TLR agonists in pediatric IBD patients; the possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen Pediatr Allergy Immunol 2009.
  • Harumi Jyonouchi Food Allergy and Autism Spectrum Disorders: Is there a link? Current Allergy and Asthma Reports. 2009; 9:194-201.
  • Jyonouchi H. Non-IgE mediated food allergy Inflamm Allergy Drug Targets. 2008 Sep;7(3):173-80. Review. PMID: 18782024 [PubMed - indexed for MEDLINE]
  • Ward CM, Geng L, Jyonouchi H. Fetal sensitization to cow's milk protein and wheat: cow's milk protein and wheat-specific TNF-alpha production by umbilical cord blood cells and subsequent decline of TNF-alpha production by peripheral blood mononuclear cells following dietary intervention. Pediatr Allergy Immunol. 2007 Jun;18(4):276-80. PMID: 17584308 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Geng L, Törüner GA, Vinekar K, Feng D, Fitzgerald-Bocarsly P. Monozygous twins with a microdeletion syndrome involving BTK, DDP1, and two other genes; evidence of intact dendritic cell development and TLR responses. Eur J Pediatr. 2007 May 23; [Epub ahead of print] PMID: 17520285 [PubMed - as supplied by publisher]
  • Ward CM, Jyonouchi H, Kotenko SV, Smirnov SV, Patel R, Aguila H, McSherry G, Dashefsky B, Holland SM. Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency. Eur J Pediatr. 2007 Sep;166(9):981-5. Epub 2006 Nov 21. PMID: 17120031 [PubMed - in process]
  • Jyonouchi H, Lien KW, Aguila H, Spinnato GG, Sabharwal S, Pletcher BA. SAPHO osteomyelitis and sarcoid dermatitis in a patient with DiGeorge syndrome. Eur J Pediatr. 2006 Jun;165(6):370-3. Epub 2006 Feb 21. PMID: 16491384 [PubMed - indexed for MEDLINE]
  • Zimmerman AW, Jyonouchi H, Comi AM, Connors SL, Milstien S, Varsou A, Heyes MP. Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol. 2005 Sep;33(3):195-201. PMID: 16139734 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Geng L, Ruby A, Reddy C, Zimmerman-Bier B. Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. J Pediatr. 2005 May;146(5):605-10. PMID: 15870662 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Geng L, Ruby A, Zimmerman-Bier B. Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention. Neuropsychobiology. 2005;51(2):77-85. PMID: 15741748 [PubMed - indexed for MEDLINE]
  • Jyonouchi H. Airway epithelium and apoptosis. Apoptosis. 1999 Dec;4(6):407-17. PMID: 14634325 [PubMed]
  • Jyonouchi H, Sun S, Kelly A, Rimell FL. Effects of exogenous interferon gamma on patients with treatment-resistant chronic rhinosinusitis and dysregulated interferon gamma production: a pilot study. Arch Otolaryngol Head Neck Surg. 2003 May;129(5):563-9. PMID: 12759271 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Winship T, Kuchan MJ. Dietary ribonucleotides increase antigen-specific type 1 T-helper cells in the regional draining lymph nodes in young BALB/cJ mice. Nutrition. 2003 Jan;19(1):41-6. PMID: 12507638 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology. 2002;46(2):76-84. PMID: 12378124 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Le H, Rimell FL. Evidence of dysregulated cytokine production by sinus lavage and peripheral blood mononuclear cells in patients with treatment-resistant chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg. 2001 Dec;127(12):1488-94. PMID: 11735821 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Le H. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol. 2001 Nov 1;120(1-2):170-9. PMID: 11694332 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Porter VA, Cornfield DN. Polycyclic aromatic hydrocarbon diol epoxides increase cytosolic Ca(2+) of airway epithelial cells. Am J Respir Cell Mol Biol. 2001 Jul;25(1):78-83. PMID: 11472978 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Winship T, Kuchan MJ. Dietary ribonucleotides modulate type 1 and type 2 T-helper cell responses against ovalbumin in young BALB/cJ mice. J Nutr. 2001 Apr;131(4):1165-70. PMID: 11285320 [PubMed - indexed for MEDLINE]
  • Gollob JA, Veenstra KG, Jyonouchi H, Kelly AM, Ferrieri P, Panka DJ, Altare F, Fieschi C, Casanova JL, Frank DA, Mier JW. Impairment of STAT activation by IL-12 in a patient with atypical mycobacterial and staphylococcal infections. J Immunol. 2000 Oct 1;165(7):4120-6. PMID: 11034424 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Abiru T, Winship T, Kuchan MJ. Dietary nucleotides modulate antigen-specific type 1 and type 2 t-cell responses in young c57bl/6 mice. Nutrition. 2000 Jun;16(6):442-6. PMID: 10869901 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Iijima K, Gross MD. Antitumor activity of astaxanthin and its mode of action. Nutr Cancer. 2000;36(1):59-65. PMID: 10798217 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Kennedy CA, Rimell FL. Interferon gamma levels in the sinus, ear, and airway in a rabbit sinusitis model induced by Bacteroides inoculation. Arch Otolaryngol Head Neck Surg. 2000 Apr;126(4):529-32. PMID: 10772309 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Rimell FL. Cytokine production by sinus lavage, bronchial lavage, and blood mononuclear cells in chronic rhinosinusitis with or without atopy. Arch Otolaryngol Head Neck Surg. 2000 Apr;126(4):522-8. PMID: 10772308 [PubMed - indexed for MEDLINE]
  • Iijima K, Sun S, Cyong JC, Jyonouchi H. Juzen-taiho-to, a Japanese herbal medicine, modulates type 1 and type 2 T cell responses in old BALB/c mice. Am J Chin Med. 1999;27(2):191-203. PMID: 10467453 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Kennedy CA, Roche AK, Kajander KC, Miller JR, Germaine GR, Rimell FL. Localized sinus inflammation in a rabbit sinusitis model induced by Bacteroides fragilis is accompanied by rigorous immune responses. Otolaryngol Head Neck Surg. 1999 Jun;120(6):869-75. PMID: 10352442 [PubMed - indexed for MEDLINE]
  • Kennedy CA, Jyonouchi H, Kajander KC, Sun S, Rimell FL. Middle ear pathologic changes associated with chronic anaerobic sinusitis in rabbits. Laryngoscope. 1999 Mar;109(3):498-503. PMID: 10089983 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Iijima K, Wang M, Hecht SS. Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol. Carcinogenesis. 1999 Jan;20(1):139-45. PMID: 9934861 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Abiru T, Chareancholvanich S, Ingbar DH. The effects of hyperoxic injury and antioxidant vitamins on death and proliferation of human small airway epithelial cells. Am J Respir Cell Mol Biol. 1998 Sep;19(3):426-36. PMID: 9730870 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Kennedy CA, Kajander KC, Rimell FL. IgG antibody levels in the sinus, ear, and airway in a rabbit model of sinusitis with Bacteroides. Arch Otolaryngol Head Neck Surg. 1998 Jul;124(7):767-72. PMID: 9677111 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S. The actions of polynucleotides on effector stage cloned murine T-helper cells differ in each subset and depend on antigen concentration. J Nutr. 1997 Mar;127(3):411-7. PMID: 9082024 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Mizokami M, Ingbar DH. Cell density and antioxidant vitamins determine the effects of hyperoxia on proliferation and death of MDCK epithelial cells. Nutr Cancer. 1997;28(2):115-24. PMID: 9290115 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Sato S. Nucleotide-free diet suppresses antigen-driven cytokine production by primed T cells: effects of supplemental nucleotides and dietary fatty acids. Nutrition. 1996 Sep;12(9):608-15. PMID: 8878170 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S. An orally supplemented mononucleotide mixture prevents the decrease in T cell-dependent humoral immunity in C57BL/6 mice fed a nucleotide-free diet. J Nutr. 1996 Jun;126(6):1586-93. PMID: 8648432 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Mizokami M, Gross MD. Effects of various carotenoids on cloned, effector-stage T-helper cell activity. Nutr Cancer. 1996;26(3):313-24. PMID: 8910913 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Tomita Y, Gross MD. Astaxanthin, a carotenoid without vitamin A activity, augments antibody responses in cultures including T-helper cell clones and suboptimal doses of antigen. J Nutr. 1995 Oct;125(10):2483-92. PMID: 7562082 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Goodman D, Yokoyama H, Sato S. Dietary fatty acid modulates actions of nucleotides on humoral immune responses. Nutrition. 1995 Sep-Oct;11(5):437-43. PMID: 8748195 [PubMed - indexed for MEDLINE]
  • Loechelt BJ, Shapiro RS, Jyonouchi H, Filipovich AH. Mismatched bone marrow transplantation for Omenn syndrome: a variant of severe combined immunodeficiency. Bone Marrow Transplant. 1995 Sep;16(3):381-5. PMID: 8535310 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Zhang-Shanbhag L, Yokoyama H. Polynucleotides compensate for impaired T-dependent antibody production induced in C57B1/6 mice by a nucleotide-free diet both in vivo and in vitro, but a mononucleotide-nucleoside mixture is effective only in vivo. J Nutr. 1995 Jun;125(6):1578-86. PMID: 7540201 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Sun S, Gross M. Effect of carotenoids on in vitro immunoglobulin production by human peripheral blood mononuclear cells: astaxanthin, a carotenoid without vitamin A activity, enhances in vitro immunoglobulin production in response to a T-dependent stimulant and antigen. Nutr Cancer. 1995;23(2):171-83. PMID: 7644386 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Zhang-Shanbhag L, Tomita Y, Yokoyama H. Nucleotide-free diet impairs T-helper cell functions in antibody production in response to T-dependent antigens in normal C57B1/6 mice. J Nutr. 1994 Apr;124(4):475-84. PMID: 8145068 [PubMed - indexed for MEDLINE]
  • Jyonouchi H. Nucleotide actions on humoral immune responses. J Nutr. 1994 Jan;124(1 Suppl):138S-143S. Review. PMID: 8283304 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Zhang L, Gross M, Tomita Y. Immunomodulating actions of carotenoids: enhancement of in vivo and in vitro antibody production to T-dependent antigens. Nutr Cancer. 1994;21(1):47-58. PMID: 8183722 [PubMed - indexed for MEDLINE]
  • Loechelt BJ, Egeler M, Filipovich AH, Jyonouchi H, Shapiro RS. Immunosuppression: preliminary results of alternative maintenance therapy for familial hemophagocytic lymphohistocytosis (FHL). Med Pediatr Oncol. 1994;22(5):325-8. PMID: 8127256 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Zhang-Shanbhag L, Georgieff M, Tomita Y. Immunomodulating actions of nucleotides: enhancement of immunoglobulin production by human cord blood lymphocytes. Pediatr Res. 1993 Nov;34(5):565-71. PMID: 8284090 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Zhang L, Tomita Y. Studies of immunomodulating actions of RNA/nucleotides. RNA/nucleotides enhance in vitro immunoglobulin production by human peripheral blood mononuclear cells in response to T-dependent stimuli. Pediatr Res. 1993 May;33(5):458-65. PMID: 7685517 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Zhang L, Tomita Y. Studies of immunomodulating actions of carotenoids. II. Astaxanthin enhances in vitro antibody production to T-dependent antigens without facilitating polyclonal B-cell activation. Nutr Cancer. 1993;19(3):269-80. PMID: 8346076 [PubMed - indexed for MEDLINE]
  • Tomita Y, Jyonouchi H, Engelman RW, Day NK, Good RA. Preventive action of carotenoids on the development of lymphadenopathy and proteinuria in MRL-lpr/lpr mice. Autoimmunity. 1993;16(2):95-102. PMID: 8180322 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Hill RJ, Good RA. RNA/nucleotide enhances antibody production in vitro and is moderately mitogenic to murine spleen lymphocytes. Proc Soc Exp Biol Med. 1992 May;200(1):101-8. PMID: 1373897 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Voss RM, Good RA. Zinc depletion modifies CD5 expression by 70Z/3 murine pre-B leukemia cell line. Proc Soc Exp Biol Med. 1991 Dec;198(3):818-25. PMID: 1719563 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Voss RM, Good RA. NZB serum factor (NZB-SF)-B precursor cell maturation factor. II. In vivo effects of NZB-SF or mAb against NZB-SF on B lineage cell populations. Clin Immunol Immunopathol. 1991 Jun;59(3):388-97. PMID: 1709397 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Voss RM, Krishna S, Urval K, Sjahli H, Welty PB, Good RA. Soluble Fc epsilon R II levels in normal children and patients with immunodeficiency diseases. J Allergy Clin Immunol. 1991 May;87(5):965-70. PMID: 1827480 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Voss RM, Good RA. NZB serum factor (NZB-SF): B precursor cell maturation factor identified in murine lupus. I. Identification of 60-kDa glycoprotein as the major component from both spleen cell supernatant and serum. Cell Immunol. 1991 Jan;132(1):223-35. PMID: 2065358 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Hill RJ, Tomita Y, Good RA. Studies of immunomodulating actions of carotenoids. I. Effects of beta-carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in vitro culture system. Nutr Cancer. 1991;16(2):93-105. PMID: 1796012 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Voss RM, Good RA. Up-regulation and down-regulation of cell surface and mRNA expression of CD5 antigen by various humoral factors on murine 70Z/3 pre-B cell leukemia cell line: IL-4 down-regulates CD5 antigen expression. Cell Immunol. 1990 Oct 1;130(1):66-78. PMID: 1697787 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Voss RM, Good RA. The presence of autoantibodies specific for NZB serum factors in adult NZB mice and the establishment of monoclonal autoantibodies against these humoral factors. Cell Immunol. 1988 Apr 15;113(1):158-74. PMID: 3284656 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Voss RM, Good RA. IL 1-like activities present in murine amniotic fluid. A significantly larger amount of IL 1 beta-like activity is present in the amniotic fluid of autoimmune NZB mice. J Immunol. 1987 May 15;138(10):3300-7. PMID: 3553325 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Kimmel MD, Lee G, Kincade PW, Good RA. Humoral factors in very young NZB mice that enhance the maturation of normal B cell precursors. Partial purification and characterization. J Immunol. 1985 Sep;135(3):1891-9. PMID: 3926891 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Kincade PW, Good RA. Age-dependent changes in B lymphocyte lineage cell populations of autoimmune-prone BXSB mice. J Immunol. 1985 Feb;134(2):858-64. PMID: 2856930 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Kincade PW. Precocious and enhanced functional maturation of B lineage cells in New Zealand Black mice during embryonic development. J Exp Med. 1984 Apr 1;159(4):1277-82. PMID: 6608574 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Kincade PW, Misra HP. Analysis of the effects of erythrocytes on mitogen-dependent clonal proliferation of murine B lymphocytes. Cell Immunol. 1984 Jan;83(1):189-98. PMID: 6607124 [PubMed - indexed for MEDLINE]
  • Kincade PW, Jyonouchi H, Landreth KS, Engelhard D, Beare MH, Lee G, Good RA. Factors affecting normal and malignant B lymphocyte precursors. Curr Top Microbiol Immunol. 1984;113:104-8. No abstract available. PMID: 6332710 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Kincade PW, Good RA, Gershwin ME. B lymphocyte lineage cells in newborn and very young NZB mice: evidence for regulatory disorders affecting B cell formation. J Immunol. 1983 Nov;131(5):2219-25. PMID: 6605377 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Kincade PW. Changes in B lineage cell population in liver and spleen of normal neonatal mice. J Immunol. 1983 Apr;130(4):1616-21. PMID: 6601130 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Kincade PW, Landreth KS, Lee G, Good RA, Gershwin ME. Age-dependent deficiency of B lymphocyte lineage precursors in NZB mice. J Exp Med. 1982 Jun 1;155(6):1665-78. PMID: 6210740 [PubMed - indexed for MEDLINE]
  • Kincade PW, Jyonouchi H, Landreth KS, Lee G. B-lymphocyte precursors in immunodeficient, autoimmune and anemic mice. Immunol Rev. 1982;64:81-98. Review. No abstract available. PMID: 7044953 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Cyong JC, Shen FW, Fernandes G, Day NK, Good RA. Alteration of murine serum lipase activity after allogeneic bone marrow transplantation. Clin Immunol Immunopathol. 1982 Jan;22(1):94-104. No abstract available. PMID: 6749356 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Kincade PW, Good RA. Immunosuppression of marrow B lymphocytes by administration of Corynebacterium parvum in mice. J Immunol. 1981 Dec;127(6):2502-7. No abstract available. PMID: 6457877 [PubMed - indexed for MEDLINE]
  • Jyonouchi H, Kincade PW, Good RA, Fernandes G. Reciprocal transfer of abnormalities in clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice. J Immunol. 1981 Sep;127(3):1232-5. PMID: 6973583 [PubMed - indexed for MEDLINE]

 

      

 

 

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